Common Dermatological Diseases Research Articles

Microscopic Menaces: The Impact of Mites on Human Health.

Mites are highly prevalent arthropods that infest diverse ecological niches globally. Approximately 55,000 species of mites have been identified but many more are yet to be discovered. Of the ones we do know about, most go unnoticed by humans and animals. However, there are several species from the Acariformes superorder that exert a significant impact on global human health. House dust mites are a major source of inhaled allergens, affecting 10-20% of the world's population; storage mites also cause a significant allergy in susceptible individuals; chiggers are the sole vectors for the bacterium that causes scrub typhus; Demodex mites are part of the normal microfauna of humans and their pets, but under certain conditions populations grow out of control and affect the integrity of the integumentary system; and scabies mites cause one of the most common dermatological diseases worldwide. On the other hand, recent genome sequences of mites provide novel tools for mite control and the development of new biomaterial with applications in biomedicine. Despite the palpable disease burden, mites remain understudied in parasitological research. By better understanding mite biology and disease processes, researchers can identify new ways to diagnose, manage, and prevent common mite-induced afflictions. This knowledge can lead to improved clinical outcomes and reduced disease burden from these remarkably widespread yet understudied creatures.

Exploration of the causality of frailty index on psoriasis: A Mendelian randomization study.

Frailty is associated with a variety of diseases, but the relationship between frailty and psoriasis remains unclear. First, we conducted a two-sample Mendelian randomization based on genome-wide association studies (GWAS) to investigate genetic causality between frailty index and common diseases in dermatology. Inverse variance weighted was used to estimate causality. Second, expression quantitative trait locus (eQTLs) analysis was conducted to identify the genes affected by Single nucleotide polymorphisms (SNPs). Third, we performed function and pathway enrichment, transcriptome-wide association studies (TWAS) analysis based on eQTLs. It was shown that the rise of frailty index could increase the risk of psoriasis (IVW, beta=0.916, OR=2.500, 95%CI:1.418-4.408, p=0.002) through Mendelian randomization (MR), and there was no heterogeneity and pleiotropy. There was no causality between the frailty index and other common diseases in dermatology. We found 31 eQTLs based on strongly correlated SNPs in the causality. TWAS analysis found that the expressions of four genes were closely related to psoriasis, including HLA-DQA1, HLA-DQA2, HLA-DRB1 and HLA-DQB1. It suggested that the frailty index had a significant positive causality on the risk of psoriasis, which was well documented by combined genomic, transcriptome, and proteome analyses.

Atopy in chronic urticaria: an important yet overlooked issue.

Chronic urticaria (CU) is one of the most common dermatological diseases and has a significant impact on the quality of life of patients. However, the pathogenesis of this disease remains unclear. Autoimmunity in chronic spontaneous urticaria (CSU) has received considerable attention and has been studied previously. Atopy is an important characteristic of CU; however, it has not been fully recognized. Atopy predisposes individuals to immune responses to allergens, leading to type 2 inflammation and immunoglobulin E (IgE) overproduction. Compared with healthy individuals, patients with CU have a higher proportion of atopy, and an atopic background is correlated with the clinical characteristics of CU. The total IgE levels in patients with CU is significantly higher than those in healthy individuals. Although its level is not higher than that in classic allergic diseases, it is closely related to CU. Exogenous allergens, auto-allergens, and specific IgEs, which are closely related to atopy, have been reported, and their roles in CU pathogenesis are also being studied. Local and systemic atopic inflammation is present in patients with CU. This review summarizes the current knowledge regarding atopy and CU, speculating that there are CU subtypes, such as atopic CSU or atopic chronic inducible urticaria (CIndU) and that atopy may be involved in the pathogenesis of CU. These findings provide a new perspective for a comprehensive understanding of the clinical features of CU and further research regarding its pathogenesis.

A patient with severe acne: therapy perspectives

Acne is a common dermatological disease that peaks between 12 and 25. The tendency of inflammatory elements to appear on the skin, especially the face, leads to psycho-emotional imbalance and significantly reduces the patient’s quality of life. In 95% of cases, the outcome of acne is the formation of cicatricial deformities, the treatment of which often takes years. If inflammatory elements are present, treatment should be aimed at ensuring a long-term remission of the disease, including preventing the formation of new scars.
 This work aims to determine the efficacy and safety of acne treatment using systemic isotretinoin.
 The article presents the results of systemic isotretinoin use in severe forms of acne and acne that is resistant to standard treatments based on clinical cases. It was proved that the benefits obtained from isotretinoin usage are much more significant than the possible risk of side effects, especially if the patient’s skin tends to scar. The latest data on the etiology and pathogenesis of cicatricial deformities is presented. A review of modern techniques for the correction of post-acne cicatricial deformities was carried out.
 Isotretinoin is clinically proven to be highly effective and safety safe for both severe acne.
 The use of isotretinoin to treat acne is effective and reduces the risk of scarring.

Knowledge Attitude And Practice Regarding Superficial Fungal Infections In Dermatology Patients In Eastern Nepal

Introduction: Superficial fungal infection is one of the most common diseases in dermatology evolving like an epidemic. Hence further research is necessary to minimize the occurrence and prevention of the disease. Objectives: To assess the knowledge, attitude and practice about superficial fungal infection and implicate the result in educating the patients thereby minimizing its further recurrence and re-infections. Methodology: A hospital based observational descriptive quantitative crosssectional study was conducted in all patients with superficial fungal infections attending dermatology outpatient department at Birat Medical College Teaching Hospital. A selfdesigned questionnaire which was double translated by two individuals in different translations and validated was used to assess knowledge, attitude and practice (KAP) regarding superficial fungal infections. Data were entered in Microsoft excel and analyzed in terms of proportions and percentage. Results: Out of total 162 patients participating in the study, less than half of the study population was aware that it was a fungal infection; majority did not know how to apply medication in an appropriate technique. They strongly believed that hot weather was the cause. They practiced daily bath, but did not change their clothes often. They preferred taking over the counter medications and visited dermatologists less often and did not complete the total dose of prescribed medication and shared their prescription with their family members for similar problem. Consclusion: All clinicians treating with superficial fungal infection should emphasize on counseling the patients regarding behavioural changes which will not only aid in treatment but will also focus on its preventive aspect.

ANTIFUNGAL ACTIVITY AND SYNERGISM OF Allium sativum, Zingiber officinale, AND Citrus limon peel ESSENTIAL OILS AGAINST Tinea capitis

The burden of Tinea infections, common dermatologic fungal diseases remains high globally, especially in Africa. This is sustained mainly by the emergence of resistance to current antifungal drugs in use. Alternative treatment and preventive measures need to be sought to eradicate these infections. Antifungal activity and synergism of garlic in combination with ginger and lemon peel essential oils against Tinea capitis is assessed using inhibition assays. Ginger, lemons, and garlic samples were randomly collected from the Nakuru town market in Nakuru County, Kenya. They were identified by a botanist and then extracted and, analyzed. Antifungal activity against Tinea capitis and synergism among extracts were assessed by the disk diffusion method and minimum inhibitory concentration (MIC), respectively. The average essential oil yield for ginger, lemon, and garlic was 22%, 20%, and 16%, respectively. Ginger, lemon, and garlic essential oils depicted a comparable antifungal activity against Tinea capitis isolates (P value > 0.05). The combined essential oils formulation of ginger, lemon, and garlic showed the highest activity compared to single extracts (P > 0.05). The MIC for the combined essential oils was 6.25 mg/ml. A combination of the three extracts acts in synergy against the Tinea isolates. The rate of inhibition was directly proportional to the concentration of the extracts. Ginger, lemon, and garlic are sources of molecules that act in synergy in controlling Tinea spp infections. They can be leveraged to support the Ministry of Health in achieving its universal healthcare goal.

Quality of life and stigmatization in people with skin diseases in Europe: A large survey from the 'burden of skin diseases' EADV project.

Several large studies on the burden of skin diseases have been performed in patients recruited in hospitals or clinical centres, thus missing people with skin diseases who do not undergo a clinical consultation. To evaluate the burden of the most common dermatological diseases in adult patients across Europe, in terms of quality of life, work life, and stigmatization. Population-based survey on a representative sample of the European general population aged 18 years or older. Participants who declared to have had one or more skin problem or disease during the previous 12 months completed the Dermatology Life Quality Index questionnaire, and answered questions regarding the impact of their skin disease on daily and work life, anxiety/depression, and stigmatization. The study population included 19,915 individuals, 44.7% of whom were men. Quality of life was particularly impaired in people with hidradenitis suppurativa (HS), and sexually transmitted diseases. About a half of participants with acne, alopecia, or chronic urticaria, and about 40% of those with atopic dermatitis (AD), skin cancers, or psoriasis reported a modest to extremely large effect of the disease on their quality of life. Overall, 88.1% of participants considered their skin disease as embarrassing in personal life and 83% in work life. About half of the respondents reported sleeping difficulty, feeling tired, and impact of the disease on taking care of themselves. Concerning stigmatization, 14.5% felt to have been rejected by others because of the skin disease, and 19.2% to have been looked at with disgust. Anxiety and depression were frequently reported by patients with all the diseases. Skin diseases may heavily affect patients' daily and work life, and cause feelings of stigmatization. An early intervention is needed to avoid consequences on the patients' life course.

Assessment of Serum Apelin Levels and Its Relation to Insulin Resistance in Acne Vulgaris Patients

Abstract Introduction Apelin is one of the adipokines. Acne vulgaris is a very common dermatological disease with a multifactorial background and hyperinsulinemia and insulin resistance are considered to play a pivotal role in its development and severity. Aim To evaluate serum apelin levels in acne vulgaris patients and to reveal the possible relation between its serum levels and the insulin resistance state in acne vulgaris patients. Material and methods Thirty-two acne vulgaris patients and thirty-two healthy controls were enrolled into the study. The blood levels of apelin, insulin and glucose were measured in patients and controls. Homeostasis model assessment index (HOMA-IR) was calculated to evaluate the insulin resistance state. Results Acne vulgaris patients experienced significant higher levels of fasting insulin, serum apelin, and HOMA-IR compared to controls. Conclusions These results suggest that serum apelin and insulin resistance may have a role in the pathogenesis of acne.

Pemphigus and pemphigoids: Clinical presentation, diagnosis and therapy.

Pemphigus and pemphigoid are two potentially life-threatening groups of autoimmune diseases, characterized by autoantibodies targeting structural components of desmosomes or hemidesmosomes, respectively. Affected patients typically show itchy/painful plaques or blistering skin lesions and/or impairing mucosal blistering and erosions, which may strongly impact their quality of life. Since the milestone work of Walter Lever in 1953, who differentiated these two groups of diseases by histopathological analysis of the level of antibody-mediated skin cleavage, enormous progresses occurred. Achievements made in laboratory diagnostics now allow to identify antigen specific structural proteins of the skin that are targeted by pathogenic autoantibodies. These progresses were accompanied by an increased understanding of the pathogenesis of these diseases thanks to the establishment of animal models reproducing disease and on studies on skin and blood of affected individuals, which have been leading to novel and disease-specific treatments. Yet, given their phenotypical overlap with more common dermatological diseases, correct diagnosis and appropriate treatment are often delayed, in some cases leading to irreversible sequelae, including organ dysfunction (i.e., loss of vision in mucous membrane pemphigoid). Here, we provide a concise overview of the clinical appearance, diagnosis and therapeutic management of pemphigus and pemphigoid diseases.

OBTAINING THE EXTRACT OF CHELIDONII MAJORIS L. AS A COMPONENT OF TOPICAL PREPARATIONS IN THE THERAPY OF PSORIASIS

Psoriasis is one of the most common dermatological diseases that significantly reduces the quality of life of patients. At the same time, about 70% of them need the use of external therapy. The aim of the study was to increase the degree of extraction of active substances from plant materials in order to improve the therapeutic properties of topical preparations for the treatment of psoriasis. For the treatment of psoriasis, it is necessary to use highly concentrated alkaloid extracts of celandine; for this, an 80% solution of acetic acid was used as an extractant.

INDICATORS OF PHAGOCYTOSIS IN WOMEN WITH ACNE DURING COMPREHENSIVE TREATMENT THAT INCLUDED PRP- AND IPL-THERAPY

Introduction. Acne is one of the most common dermatological diseases. It may have a chronic course, leaving permanent marks, and in last years has been tending to have more and more severe clinical course with widespread skin lesions. According to recent studies, the development of acne is due to the combined effect of endogenous and exogenous factors, among which endocrine diseases, disorders of metabolic processes, reduced systemic immunity and phagocytic ability of mononuclear phagocytes and granulocytes at various stages of phagocytosis of pyogenic cocci, which contributes to more severe clinical course, and frequent relapse of this diseases. It was also proved that the intestinal microbiota plays an important role in the formation of homeostasis and immune response.
 The Objective of the study is to determine the evolution of phagocytosis indices in patients with acne under different comprehensive treatments, using oral antibiotics, immunotherapy (PRPtherapy), probiotics, low-dose birth control pills and IPL- therapy.
 Materials and methods. We observed 93 women with acne aged from 18 to 25 years old. In 19 (20.43%) patient mild acne was diagnosed, in 41 (44.09%) – moderate acne, in 33 (35.48%) persons – severe acne, 54 (58.06%) persons suffered from acne up to 1 year, 39 (41.93%) – from 1 to 3 years. To assess the state of phagocytosis in patients with acne vulgaris, we determined phagocytic activity (PA) and phagocytic index (PI) of polymorphonuclear leukocytes, nitro blue tetrazolium recovery test (NBT test spontaneous) and NBT-test pyrogenal stimulated by recognized methods.
 Results. Analysis of the studied parameters of phagocytosis at the end of treatment showed a significant increase in patients of the core group who were administered a comprehensive treatment which included oral antibiotic, probiotic, and low-dose birth control pills, PRP-therapy and IPLtherapy, as compared with the patients of other groups under study.
 Conclusions. Using combined therapy for women with acne occurring against the backdrop of a sluggish process of phagocytosis and concomittant intestinal dysbiosis leads to normalization of the leading indices of phagocytosis (PI, PA, NBT tests both spontaneous and stimulated), and enhances their phagocytic activity both during capture and formation of bactericidal activity and in the final stages of phagocytosis justifying the feasibility of a combined use of antibiotics, probiotic, low-dose birth control pills PRP-therapy and IPL-therapy in the treatment of acne.

Effect of Shodhana and Gandhaka Rasayana in Psoriasis - A Case Study

Psoriasis is one of the most common inflammatory autoimmune dermatologic diseases. The major concerns of psoriasis are social stigma which leaves a significant emotional impact for the patient. However, systematic management strategies, diet modification and timely monitoring shows an improvement in health-related quality of life and thus an improvement in social and psychological wellbeing. Severity of psoriasis tends to fluctuate with exogenous factors like diet, environmental factors etc. Spontaneous exacerbations and remissions are usual. There IS no specific treatment protocol in the management of psoriasis. In Ayurveda the symptoms are more similar to Vata kapha predominant Kushta, more specifically Sidhma kushta. The present study is aimed to treat a 22-year-old male patient, a known case of plaque psoriasis admitted in the IPD of Kayachikitsa department, Govt. Ayurveda College, Thiruvananthapuram. Deepana, Pachana Sodhana, Samana and Rasayana were the treatment protocol included. Ayurvedic approach in a single case of psoriasis is found beneficial in correcting the inherent Agnimandya at Koshta and Dhatu level and thus arrest the progression of the autoimmune inflammatory pathology. PASI (Psoriasis Assessment Severity Scale) score was used to assess the severity of lesions. Before treatment PASI score was 5.7 which reduced to 4.2 after 2 weeks. At the time of discharge PASI score was 0. The case report shows no recurrence of symptoms on review after 4 weeks.

Dermatologic Diseases of Four-Toed Hedgehogs.

Dermatologic diseases are frequently diagnosed in the four-toed hedgehog. Common clinical signs include spine loss, scales and crusts, pruritus, alopecia, and masses. Caparinia tripilis, family Psoroptidae, is the most common mite affecting hedgehogs, and is diagnosed via light microscopy. Dermatophytosis from Trichophyton erinacei infection is a common zoonotic dermatologic disease in pet hedgehogs. Diagnosis is through fungal culture. Neoplasia is another major cause of dermatologic diseases in four-toed hedgehogs. The diagnostic approach typically begins with a fine-needle aspirate but often requires a biopsy for a definitive diagnosis.

The frequency of warts among patients attending at department of dermatology and venereology, in Al-Sadar Hospital in Baghdad, IRAQ

Background: Human papilloma virus [HPV] infection is a very common dermatological disease, as most people will experience infection during their lifetime. Objective: To find the frequency of warts among patients attending at Department of Dermatology and Venereology, in Al-Sadar Hospital in Baghdad. IRAQ. Patients and Methods: A descriptive cross sectional study was conducted during the period from the first of January to 31 of March 2021. This study included 7453 patients. Results: the percentage of patients with warts was 1171[15.71%] with the higher number and percentage in females 622 [53.12 %] than in males 549[46.88 %]. The differences among age groups were significant (P=0.03). Also the differences due to month were significant. Conclusions: There was high frequency of viral warts among patients attending at Department of Dermatology and Venereology at Al-Sadar Hospital especially at the children and young adult age groups.

Management of Oral Lichen Planus: Recent updates

Oral lichen planus is one of the most common dermatological disease affecting the oral mucosa. It is characterized by periods of remission and exacerbation. Regular follow up is needed for some severe forms of oral lichen planus. Various treatment modalities are reported in the literature and this article discusses about some of the recent medications used in patients with oral lichen planus.

Analysis of Prescribing Practices in the Dermatology Outpatient Department of a Tertiary Care Teaching Hospital.

Introduction The practice of appropriately prescribing and delivering pharmaceuticals to the right patient for the diagnosis, prevention, and treatment of diseases is referred to as "rational drug usage". Patients should receive pharmaceuticals that are appropriate for their clinical needs, given in doses that meet their needs, for long enough periods of time, and for the least amount of money possible. Minimizing drug therapy costs without sacrificing therapeutic effectiveness, avoiding unnecessary adverse medication reactions and drug-drug interactions, and improving therapeutic care while encouraging patient adherence are the main objectives of rational drug usage. The present study was planned to assess the current prescribing practices in the dermatology outpatient department of a tertiary care hospital. Materials and methods A prospective descriptive study was conducted in the department of dermatology at a tertiary care teaching hospital after receiving permission from the institutional ethics committee. The study was conducted from November 2022 to February 2023 and followed the WHO recommendation for sample size. A total of 617 prescriptions were analyzed thoroughly. Results Regarding the demographic profile of the 617 prescriptions, 299 were male and 318 were female. The patients had diverse diseases, with the most common being tinea infection (57 cases, 9%) and acne vulgaris (53 cases, 8.5%), followed by scabies (38 cases, 6%), urticaria, and eczema (30 cases, 5%). Twenty-six (4%) prescriptions were not written in capital letters, 86 (13%) prescriptions did not mention the route of drug administration, and the consultant's or physician's name and signature were missing in 13 (2%), and six (1%) prescriptions, respectively. None of the prescriptions were written using the generic names of the drugs. Polypharmacy was observed in 51 (8%) prescriptions. Moreover, potential drug-drug interactions were identified in 12 (1.9%) instances. The most prescribed drugs were antihistaminics, with 393 (23%) prescriptions. Antifungal drugs were the second most prescribed, with 291 (17%) prescriptions. Corticosteroids were also commonly prescribed, with 271 (16%) prescriptions. Antibiotics were prescribed in 168 (10%) cases; other drugs were prescribed in 597 (35%) cases, including retinoids, anti-scabies drugs, antileprotic drugs, moisturizers, sunscreens, etc. Conclusion The study highlighted the prescription errors in writing the drugs in capital letters, mentioning the dose, route, and frequency of drugs, etc. It provided insight into the common diseases in dermatology and routine prescribing patterns and addressed the frequency of polypharmacy and drug-drug interactions.

A STUDY OF THE PATTERN OF DERMATOLOGICALAND SEXUALLY TRANSMITTED DISEASES IN ADOLESCENTS AND YOUNG ADULTS IN EASTERN UTTAR PRADESH

Introduction: Adolescents and young adults are high-risk groups for skin and sexually transmitted diseases, especially in developing or lowincome countries. The present study was conducted to give an insight on the various dermatological and sexually transmitted diseases in adolescents and young adults in the age group of 10-24 years. Materials and Methods: This is a retrospective study where all the records of the patients who presented at a speciality clinic for adolescents and young adults were assessed. Those patients who consulted the treating dermatologist were included in the study. The records of 422 patients between the ages of 10 and 24 years, attending the tertiary care centre in Eastern Uttar Pradesh during 2020 and 2021 were included in this retrospective study. Results: Out of 422 patients, there were 164 males and 258 females. The mean age of all patients was found 19.433.57 years. The most common dermatological disease was Dermatophytic fungal infections seen in 67(15.8%) patients followed by chronic Idiopathic Urticaria in 57(13.5 %) patients followed by acne Vulgaris in 46(10.9%) patients. Among infestations, Scabies was seen in 41 (9.7%) patients. The next common dermatoses were Post Inammatory Hyperpigmentation seen in 40 patients. In hair disorders, telogen efuvium was the most common manifestation seen in 39(9.2%) patients. Among sexually transmitted infections (STI), Vulvovaginal Candidiasis was diagnosed in 19 patients and genital warts in one male patient. Conclusion: Fungal infections are common in adolescents and young adults. Acne Vulgaris is also common in this age group

Lichen sclerosus: The 2023 update.

Lichen sclerosus (LS) is an underdiagnosed inflammatory mucocutaneous condition affecting the anogenital areas. Postmenopausal women are predominantly affected and, to a lesser extent, men, prepubertal children, and adolescents. The etiology of LS is still unknown. Hormonal status, frequent trauma and autoimmune diseases are well-known associations for LS, yet infections do not seem to be clear risk factors. LS pathogenesis involves factors such as a genetic predisposition and an immune-mediated Th1-specific IFNγ-induced phenotype. Furthermore, there is a distinct expression of tissue remodeling associated genes as well as microRNAs. Oxidative stress with lipid and DNA peroxidation provides an enabling microenvironment to autoimmunity and carcinogenesis. Circulating IgG autoantibodies against the extracellular matrix protein 1 and hemidesmosome may contribute to the progression of LS or simply represent an epiphenomenon. The typical clinical picture includes chronic whitish atrophic patches along with itching and soreness in the vulvar, perianal and penile regions. In addition to genital scarring, and sexual and urinary dysfunction, LS may also lead to squamous cell carcinoma. Disseminated extragenital LS and oral LS are also reported. The diagnosis is usually clinical; however, a skin biopsy should be performed in case of an unclear clinical picture, treatment failure or suspicion of a neoplasm. The gold-standard therapy is the long-term application of ultrapotent or potent topical corticosteroids and, alternatively, topical calcineurin inhibitors such as pimecrolimus or tacrolimus. Collectively, LS is a common dermatological disease with a so far incompletely understood pathogenesis and only limited treatment options. To foster translational research in LS, we provide here an update on its clinical features, pathogenesis, diagnosis and (emerging) treatment options.

Inhibition of Mast Cell Degranulation in Atopic Dermatitis by Celastrol through Suppressing MRGPRX2.

Atopic dermatitis is a common dermatological disease, and mast cell degranulation is believed to be related with the progression of atopic dermatitis. Mas-related G protein-coupled receptor-X2 (MRGPRX2), and calcium release-activated calcium channel protein 1-2 (ORAI-1, ORAI-2) are involved in mast cell degranulation. Celastrol is an active monomer of Tripterygium wilfordii, and it presents an antiatopic role. 2,4-Dinitrofluorobenzene (DNFB) and compound 48/80 (C 48/80) were used to establish a slow and acute scratching animal model, respectively. Hematoxylin-eosin and toluidine blue staining was used to investigate tissue injury. Inflammatory factor concentration was measured with ELISA. The expression of MRGPRX2, ORAI-1, and ORAI-2 was detected with immunohistochemistry (IHC) staining. Gene expression profiling and microRNA array were performed to investigate gene differential expression. Celastrol greatly inhibited atopic dermatitis-related tissues injury, mast cell production, histamine release, scratching level, inflammatory factor expression, and activation of MRGPRX2/ORAI axis in the DNFB-induced atopic dermatitis model. The influence of Celastrol on atopic dermatitis was remarkably reversed by overexpression of MRGPRX2. We found that the improvements of atopic dermatitis caused by Celastrol were reversed by treatment with MRGPRX2OE, indicating that Celastrol might affect atopic dermatitis through MRGPRX2. This study might provide a novel thought for the prevention and treatment of atopic dermatitis by regulating MRGPRX2.

Ayurvedic management of Eka Kushta w.s.r to Psoriasis: A Case study

ABSTRACT:
 Eka Kushta is a type of Kshudra Kushta occurring mainly due to imbalance of Vata and Kapha Doshas, resembling Psoriasis in its clinical manifestations. Psoriasis is one of the most common dermatologic diseases, affecting up to 2% of world population. Childhood psoriasis is relatively common with prevalence of 1-3% of general population. Psoriasis is an immune mediated disease clinically characterized by erythematous, sharply demarcated papules and rounded plaques covered by silvery scales. The most commonly involved areas are the  elbows, gluteal cleft, knees and scalp. In Ayurveda various treatment modalities have been described in the  management of Eka kushta  which includes Shodana and Shamana. Hence, in the present case report a 8 year male child who came to Kaumarabhritya Out Patient Department presenting with symptoms of Eka kushta on elbows, knees, hands and feet, was treated with Shodana chikitsai.e, Virechana followed by Vasti and Shamana chikitsa i.e internal medication. The symptoms were assessed with the help PASI score at pre and post therapy, and the results were noted. After treatment satisfactory results were observed.
 Key words :Eka kushta, Psoriasis, PASI Score, Shodana chikitsa, Shamana chikitsa
 Corresponding Author:
 M.Avinash Reddy,
 PG Scholar,
 Department of Kaumarabhritya,
 S.V. Ayurvedic College, Tirupati,
 Andhra Pradesh. India.
 Email Id: reddyavinash771@gmail.com